Sorry to be a wet blanket about 5) Alzheimer’s drug, but this is a monoclonal antibody that is supposed to clear up the amyloid – the same approach that has failed dozens of times. If your drug only ‘works’ in the highest dose (no dose-response effect), and then it only slows down the disease somewhat, you are not treating the disease, you are treating the symptoms.
Sorry to be a wet blanket about 5) Alzheimer’s drug, but this is a monoclonal antibody that is supposed to clear up the amyloid – the same approach that has failed dozens of times. If your drug only ‘works’ in the highest dose (no dose-response effect), and then it only slows down the disease somewhat, you are not treating the disease, you are treating the symptoms.
There is a promising approach that is completely novel, from Leucadia Therapeutics (I’m not associated with them in any way): https://www.youtube.com/watch?v=sydpGol7CcA&list=LLbxgTiFNmrOTutfscry7HYg&index=22&t=0s .
I think my wording was careful. I don’t expect that we have a cure.
I subscribed for the in depth benchmarking and performance posts, but stayed for those link collections.
So I just wanted to say I appreciate your blog and the wonderful mix of topics 👏